MI-3(MENIN-MLL INHIBITOR 3)

Name	MI-3
Synonyms	MI3 MI-3 MI 3 4-[4-(4 THIENO[2 5-dihydro-5 5-DIHYDRO-5 3-D]PYRIMIDINE Menin-MLL inhibitor 3 MENIN-MLL INHIBITOR 3 MI-3 (Menin-MLL Inhibitor) MI-3(MENIN-MLL INHIBITOR 3) 5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL) 5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl) 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
CAS	1271738-59-0

Molecular Formula	C18H25N5S2
Molar Mass	375.55
Density	1.36±0.1 g/cm3(Predicted)
Boling Point	527.9±60.0 °C(Predicted)
pKa	9.59±0.40(Predicted)
Storage Condition	-20℃
In vitro study	In HEK293 cells, MI-3 approached the protein target and effectively inhibited the interaction by menin-MLL-AF9. MI-3 the MLL fusion protein-mediated leukemic transformation is effectively blocked by down-regulating the expression of a target gene required for the oncogenic activity of the MLL fusion protein. In human MLL leukemia cell lines carrying different MLL translocations, MI-3 effectively blocked cell differentiation and induced apoptosis.

Last Update：2024-01-02 23:10:35

use	MI-3 (Menin-MLL inhibitor) can inhibit the carcinogenic activity of MLL fusion protein in leukemia.
biological activity	MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
In vitro study	In HEK293 cells, MI-3 approach protein targets and effectively inhibit menin-MLL-AF9 interactions. MI-3 can effectively block the transformation of leukemia mediated by MLL fusion protein by down-regulating the expression of target genes required for oncogenic activity of MLL fusion protein. In human MLL leukemia cell lines carrying different MLL translocation, MI-3 effectively block cell differentiation and induce cell apoptosis.
target	IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL)

Last Update：2024-04-09 20:49:11

Product Name: MI-3 Visit Supplier Webpage Request for quotation
CAS: 1271738-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: MI-3 Visit Supplier Webpage Request for quotation
CAS: 1271738-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

MI-3(MENIN-MLL INHIBITOR 3)

MI-3(MENIN-MLL INHIBITOR 3) Request for Quotation